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After defining your Departments and Roles, you need to set the department to role combination of every user. Then for every Role, you setup the privileges that specify what actions are allowed for that role. For eg.. Add Project Task - Can anyone in your Org Organisation create a new projecttask? If yes, you will Grant this permission to your role - 'Staff'.
Security is applied based on a combination of WHAT ROLE a USER plays in WHICH DEPARTMENT (Every project in Celoxis has a department. And objects such as tasks, time, expense, documents and discussions are all attached to a project and hence a department.) Please click here to read more on how security works.
